منابع مشابه
The Role of Long Non-Coding RNAs in Ovarian Cancer
Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-co...
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Until recently, RNA has been viewed as a simple “working copy” of the genomic DNA, simply transporting information from the genome into the proteins. In the 1980s, this picture changed, to certain extent, with the discovery of ribozymes and the realization that the ribosome is essentially an “RNA machine”. Since the turn of the millenium, however, RNA has moved from a fringe topic to a central ...
متن کاملLong non-coding RNAs and their significance in human diseases
Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
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The central dogma of molecular biology characterizes RNA as a simple working copy of DNA, simply transporting a code from the genome into the protein biosynthesis machinery [14, 15]. However, recent discovery of RNA interference (RNAi) [25, 26], the post transcriptional silencing of gene expression via interactions between mRNAs and their regulatory RNAs, has drastically changed the picture tha...
متن کاملthe role of long non-coding rnas in ovarian cancer
background: ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. however, the aim of this review was to investigate the role of long n...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.1317